The present work is on a two-fluid approachbased simulation of three-dimensional blood flow in an elevated dimension bended-bifurcated microchannel. Blood flow is considered as the dense suspension flow of red blood cells suspended into blood plasma. The conservation equations of blood plasma and red blood cells are solved separately. The proposed model is validated with experimental results for blood flow in a uniform rectangular microchannel. A detailed analysis of local hematocrit, at various different locations, in a bended-bifurcated microchannel is presented. The proposed model-based results capture the Zweifach-Fung or bifurcation law, at an elevated dimension of microdevices. The simulation predicts the hematocrit profiles, with a shallow peak near the outer bend wall. This is due to the movement of RBCs − in the bend portion − towards the outer bend wall and the formation of a larger cell-depletion layer in the inner bend wall; due to the centrifugal effect. Our simulation predicts the decrease in both separation efficiency and bulk flow rates with increasing inlet hematocrit. The proposed two-fluid approach can be further used to study the blood flow in realistic complex microdevices to optimize its geometry and dimensions.