Heat transfer characteristics of heat exchanger depends on its design, operating parameters and the type of fluid used. The heat transfer characteristics could be improved by suspending nanoparticle in the base fluid, which leads to increase in overall thermal conductivity and lowers thermal resistance. The most commonly used working nanofluid for experimental investigation is Al₂O₃ (Alumina) water nanofluid, where noticeable increase in energy efficiency, exergy efficiency and overall heat transfer coefficient was observed. Other commonly used nanoadditives are CuO (Copper oxide), MgO (Magnesium oxide), TiO₂ (Titanium Dioxide) and MWCNT (Multi walled carbon nano tubes). A significant increase in the overall thermal conductivity of nanofluid has been detected with the use of MWCNT nanoadditives. MWCNT based nanoadditives have been used in hybrid combination with other nanoadditives as a coolant for the heat exchanger in order to study energy/exergy performance, which is quite expensive and can be associated with high cost of MWCNT nanoadditives. In current study CuO based hybrid nanofluids (CuO-Al₂O₃, CuO-MgO, CuO-TiO₂ and CuO-MWCNT) have been prepared. The corresponding increase in energy and exergy performance has been evaluated for each nanofluid for a fixed concentration.